Flavoproteins: Structures and Mechanisms Glutamate synthase: a complex iron-sulphur flavoprotein
نویسندگان
چکیده
Glutamate synthase (GltS, EC 1.4.1.13) forms with glutamine synthetase (GS, EC 6.3.1.2, reaction 1) the main route for glutamate synthesis in micro-organisms by catalysing the NAD(P)Hdependent transfer of the amide group of glutamine to the C(2) carbon of 2-oxoglutarate (2-OG, reaction 2). The overall reaction catalysed by GS and GltS (reaction 3) is similar to the reaction of glutamate dehydrogenase (reaction 4), except for the expenditure of an extra molecule of ATP for each glutamate that is produced. Amidotransferases then can make this nitrogen atom available for amino acid biosynthesis.
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